منابع مشابه
Release of membrane-associated mucins from ocular surface epithelia.
PURPOSE Three membrane-associated mucins (MAMs)--MUC1, MUC4, and MUC16--are expressed at the ocular surface epithelium. Soluble forms of MAMs are detected in human tears, but the mechanisms of their release from the apical cells are unknown. The purpose of this study was to identify physiologic agents that induce ocular surface MAM release. METHODS An immortalized human corneal-limbal epithel...
متن کاملAlteration of ocular surface mucins in MUC5AC-DTA transgenic mice
PURPOSE To investigate the compensation of secretory mucins with membranous mucins in mice with goblet cell deficiency. METHODS A transgenic mouse model in which conjunctival goblet cells were targeted was generated, and the expression of mucins was evaluated through the toxicity of diphtheria toxin A driven by a human mucin, MUC5AC, promoter. Immunohistochemical staining, in situ hybridizati...
متن کاملAssociation of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier.
Maintenance of an intact mucosal barrier is critical to preventing damage to and infection of wet-surfaced epithelia. The mechanism of defense has been the subject of much investigation, and there is evidence now implicating O-glycosylated mucins on the epithelial cell surface. Here we investigate a new role for the carbohydrate-binding protein galectin-3 in stabilizing mucosal barriers through...
متن کاملCommensal ocular bacteria degrade mucins.
BACKGROUND/AIMS Antimicrobial activity in tears prevents infection while maintaining a commensal bacterial population. The relation between mucin and commensal bacteria was assessed to determine whether commensals possess mucinolytic activity, how degradation depends on mucin integrity, and whether mucins affect bacterial replication. METHODS Bacteria were sampled from healthy eyes and contac...
متن کاملDifferential regulation of membrane-associated mucins in the human ocular surface epithelium.
PURPOSE Membrane-associated mucins present in the apical cells of the ocular surface epithelium (MUC1, -4, and -16) are believed to contribute to the maintenance of a hydrated and wet-surfaced epithelial phenotype. Serum and retinoic acid (RA) have been used to treat drying ocular surface diseases. The goal of this study was to determine whether serum or RA regulates the production of membrane-...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2018
ISSN: 1552-5783
DOI: 10.1167/iovs.17-23623